CMC (carboxymethyl cellulose) is a carboxymethyl group substitution product of cellulose. According to its molecular weight or degree of substitution, it can be a fully soluble or insoluble polymer. The latter can be used as a weakly acidic cation exchanger for separation of neutral or basic proteins, etc.
Carboxymethyl cellulose CMC is mainly used in: carboxymethylcellulose in food, textile, construction, pesticides, medicine, cigarettes, daily chemicals, papermaking, petroleum, adhesives, additives, thickeners, stabilizers, preservatives, modifiers, sodium carboxymethyl cellulose uses in detergent, carboxymethyl cellulose in toothpaste and other industries.
In the pharmaceutical industry, it can be used as an emulsion stabilizer for injections, a binder for tablets and a film-forming agent. Some people have proved that CMC is a safe and reliable anticancer drug carrier through basic and animal experiments.
CMC uses as the membrane material, The modified dosage form of the traditional Chinese medicine Yangyin Shengji Powder - Yangyin Shengji Membrane, which can be used for skin grinding surgical wounds and traumatic wounds.
Animal model studies have shown that the film prevents wound infection and has no significant difference with gauze dressings. It is significantly better than gauze dressings in controlling the exudation of wound tissue fluid and rapid wound healing, and can reduce postoperative edema and wound irritation.
The film formulation made of polyvinyl alcohol: sodium carboxymethyl cellulose: polycarboxyethylene in the ratio of 3:6:1 is the best prescription, and the adhesion and release rate are both increased.
In increasing the adhesion of the mucoadhesive sustained-release preparation, prolonging the residence time of the preparation in the oral cavity and the efficacy of the drug in the preparation, the efficacy of the drug in the preparation is significantly improved.
Bupivacaine is a powerful local anesthetic, but it can sometimes produce serious cardiovascular side effects when it is poisoned.
Pharmaceutical studies have shown that the formulation of CIVIC as a sustained-release substance with bupivacaine solution can significantly reduce the side effects of the drug. In PRK surgery, the use of low-concentration dicaine and non-steroidal anti-inflammatory drugs combined with carboxymethyl cellulose can significantly relieve postoperative pain. Preventing peritoneal adhesions and reducing intestinal obstruction after abdominal surgery is one of the most concerned issues in clinical surgery.
The effect of CMC in reducing the degree of postoperative peritoneal adhesion was significantly better than that of sodium hyaluronate, which can be used as an effective method to prevent the occurrence of peritoneal adhesion.
CMC is used to treat liver cancer by catheter hepatic artery infusion of anticancer drugs, which can significantly prolong the residence time of the anticancer drugs in the tumor, enhance the antitumor ability, and improve the therapeutic effect.
In animal medicine, carboxymethyl cellulose cmc also has a wide range of uses. It has been reported that intraperitoneal instillation of 1% CMC solution into ewes has a significant effect on preventing dystocia in livestock and abdominal adhesions after reproductive tract surgery.